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Index > Protein center > Kirrel(Gene name) > Rat
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  • Kirrel (Gene name),
  • Kin of IRRE-like protein 1 (Protein name ),  KIRR1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Kirrel(Kirrel1;Neph1);
    Protein name:
    Kin of IRRE-like protein 1;
    Alternative:
    Nephrin-like protein 1;Kin of irregular chiasm-like protein 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains).
    Function:
    Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.
    Protein Attributes:
    Sequence length:
    789
    Sequence:
    50:
    MTLENRSTCL | MTCQSSLLPK | KPRFLSQKMW | APHLVVAYLI | FVTLALALPG | 
    100:
    TQTRFSQEPA | DQTVVAGHRA | VLPCVLLNYS | GIVQWTKDGL | ALGMGQGLKA | 
    150:
    WPRYRVVGSA | DAGQYNLEIT | DAELSDDASY | ECQATEAALR | SRRAKLTVLI | 
    200:
    PPEDTRIDGG | PVILLQAGTP | YNLTCRAFNA | KPAATIIWFR | DGTQQEGAVT | 
    250:
    STELLKDGKR | ETTISQLLIQ | PTDLDIGRVF | TCRSMNEAIP | NGKETSIELD | 
    300:
    VHHPPTVTLS | IEPQTVLEGE | RVIFTCQATA | NPEILGYRWA | KGGFLIEDAH | 
    350:
    ESRYETNVDY | SFFTEPVSCE | VDSKVGSTNV | STVVNVHFAP | RIVVYPKPTT | 
    400:
    TDIGSDVTLT | CVWVGNPPLT | LTWTKKDSNM | VLSNSNQLLL | KSVTQADAGT | 
    450:
    YTCRAIVPRI | GVAEREVPLY | VNGPPIISSE | AVQFAVRGDG | GKVECFIGST | 
    500:
    PPPDRIAWAW | KENFLEVGTL | ERYTVERTNS | GSGVLSTLTI | NNVMEADFQT | 
    550:
    HYNCTAWNSF | GPGTAIIQLE | EREVLPVGII | AGATIGAGIL | LVFSFAALVF | 
    600:
    FLYRRRKGSR | KDVTLRKLDI | KVETVNREPL | TMHSDREDDT | TSISTATRVM | 
    650:
    KAIYSSFKDD | VDLKQDLHCD | TIETREEYEM | KDPTNGYYNV | RAHEDRPSSR | 
    700:
    AVLYADYRAP | GPTRFDGRPS | SRLSHSSGYA | QLNTYSRAPA | SDYGTEPTPS | 
    750:
    GPSAPGGTDT | TSQLSYENYE | KFNSHPFPGA | AGYPTYRLGY | PQAPPSGLER | 
    789:
    TPYEAYDPIG | KYATATRFSY | TSQHSDYGQR | FQQRMQTHV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Kin of IRRE-like protein 1
    Cat.:
    E2838m
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    Packing:
    96T
    ELISA Kit for Rat Kin of IRRE-like protein 1
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    E2838h
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    ELISA Kit for Rat Kin of IRRE-like protein 1
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    E2838r
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    Packing:
    96T
    CLIA Kit for Rat Kin of IRRE-like protein 1
    Cat.:
    U2838m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Kin of IRRE-like protein 1
    Cat.:
    U2838h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Kin of IRRE-like protein 1
    Cat.:
    U2838r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Kin of IRRE-like protein 1
    Monoclonal Antibody for Rat Kin of IRRE-like protein 1
    Monoclonal Antibody for Rat Kin of IRRE-like protein 1
    Protein for Rat Kin of IRRE-like protein 1
    Protein for Rat Kin of IRRE-like protein 1
    Protein for Rat Kin of IRRE-like protein 1

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    References
    1. 1.
      Kawachi H. , Koike H. , Han G.D. , Shimizu F.
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar.
    2. 2.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      "Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability."
      Liu G. , Kaw B. , Kurfis J. , Rahmanuddin S. , Kanwar Y.S. , Chugh S.S.
      J. Clin. Invest.112:209-221(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-786;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
    4. 4.
      "Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2."
      Harita Y. , Kurihara H. , Kosako H. , Tezuka T. , Sekine T. , Igarashi T. , Hattori S.
      J. Biol. Chem.283:9177-9186(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-637 AND TYR-638 BY FYN;INTERACTION WITH GRB2
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